--- title: "ExperTox Unknown Drug Panel: How It Works | AMH Nationwide" description: "Learn how the ExperTox Unknown Drug Panel works with expert lab analysis and MRO review. Understand the process from sample to results. Call (877) 731-6362." author: "AMH Nationwide" date: "2026-08-27" tags: ["expertox unknown drug panel how it works"] canonical: "https://amhnationwide.com/expertox-unknown-drug-panel-how-it-works/" last_updated: "2026-08-27" --- # ExperTox Unknown Drug Panel: How It Works | AMH Nationwide **By AMH Nationwide** | August 27, 2026 Learn how the ExperTox Unknown Drug Panel works with expert lab analysis and MRO review. Understand the process from sample to results. Call (877) 731-6362. --- The ExperTox Unknown Drug Panel how it works involves a precise process starting with sample collection at certified sites, followed by expert lab screening and confirmation testing, and concluding with a certified Medical Review Officer review. This ensures accurate identification of unknown substances in a sample. Call (877) 731-6362. COLLECTION ## How is the sample collected for the ExperTox Unknown Drug Panel? The sample collection for the ExperTox Unknown Drug Panel begins at one of the nationwide collection sites affiliated with five national lab networks: [Quest Diagnostics](https://www.questdiagnostics.com/), [LabCorp](https://www.labcorp.com/), Omega Labs, United States Drug Testing Labs, and ExperTox. AMH Nationwide directs the requester to the appropriate collection site. Collection typically involves providing a [urine](https://amhnationwide.com/urine-drug-testing/) specimen, which is the standard matrix for this panel. The collection process follows strict chain-of-custody protocols to maintain sample integrity and prevent tampering. Specimen type: Urine Collection sites: Part of five national lab networks Chain-of-custody: Maintained throughout No online ordering: Requires contacting AMH Nationwide LAB ANALYSIS ## What happens during lab analysis of the ExperTox Unknown Drug Panel? Once collected, the specimen is sent to the ExperTox laboratory for analysis. The lab performs an initial immunoassay screening designed to detect a wide range of known and unknown substances in the urine. If the screening identifies any positive or inconclusive results, the sample undergoes confirmatory testing using advanced methods such as gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-tandem mass spectrometry (LC-MS/MS). These confirmatory tests provide precise identification and quantification of the substances present. Initial testing: Immunoassay screening for broad detection Confirmatory testing: GC-MS or LC-MS/MS for accuracy Detection capability: Known and unknown drug compounds SCREENING & CONFIRMATION ## How do screening and confirmation work together in this panel? The ExperTox Unknown Drug Panel uses a two-step process to ensure accurate results. The initial screening quickly identifies potential drug presence but may not specify exact substances. Confirmatory testing follows for any non-negative screens. This step verifies the initial findings with high specificity, ruling out false positives and detecting substances that might not be identified by screening alone. Step 1: Broad immunoassay screening Step 2: Confirmatory testing for all positives Purpose: Accurate identification and reduced false positives MEDICAL REVIEW ## What role does the Medical Review Officer play in the process? Every non-negative screen in the ExperTox Unknown Drug Panel is reviewed by a certified Medical Review Officer (MRO). The MRO evaluates the lab results in the context of the donor’s medical history and any prescription information provided. This review ensures that legitimate medical explanations are considered before finalizing the results, maintaining fairness and accuracy in reporting. Certified MRO reviews all non-negative results Considers medical and prescription information Ensures accurate and fair interpretation of results ## Need the ExperTox Unknown Drug Panel? Contact AMH Nationwide to schedule your sample collection at a certified site. Call (877) 731-6362 for guidance and next steps. [Call (877) 731-6362](tel:+18777316362)[Contact Us](https://amhnationwide.com/contact-us/) PROCESS FLOW ## What is the end-to-end process of the ExperTox Unknown Drug Panel? The process starts with AMH Nationwide directing the requester to a certified collection site affiliated with one of five national lab networks. After urine collection under chain-of-custody protocols, the sample is sent to the ExperTox lab for screening. Positive or inconclusive screens then undergo confirmatory testing. Following lab analysis, a certified Medical Review Officer reviews any non-negative results to provide a final, verified report. | Step | Description | | --- | --- | | 1. Collection | Sample collected at certified site under chain-of-custody | | 2. Screening | Immunoassay screening to detect substances | | 3. Confirmation | GC-MS or LC-MS/MS confirmatory testing on positives | | 4. MRO Review | Certified Medical Review Officer evaluates results | | 5. Reporting | Final verified results provided to requester | TEST DETAILS ## What substances can the ExperTox Unknown Drug Panel detect? The ExperTox Unknown Drug Panel is designed to detect a broad spectrum of drug compounds, including both common and uncommon substances. The unknown drug panel focuses on identifying substances that may not be included in standard drug panels, providing comprehensive detection. Because the panel targets unknown or unexpected substances, it is often used when there is a need to identify drugs not typically screened for in routine tests. Includes common drugs of abuse and prescription medications Detects unexpected or unknown substances Uses advanced confirmatory techniques for identification AMH Reviewed & Maintained By AMH Nationwide Customer Service AMH Nationwide is BBB A+ accredited and routes every order through Quest Diagnostics, LabCorp, Omega Labs, United States Drug Testing Labs, or ExperTox, all of which use multiple lab certification agencies and standards such as [SAMHSA](https://www.samhsa.gov/workplace/drug-testing)-aligned laboratory protocols, the ANSI National Accreditation Board for forensic testing and calibration, the College of American Pathologists (CAP), and Clinical Laboratory Improvement Amendments (CLIA). Every non-negative screen is reviewed by a certified Medical Review Officer as part of standard processing before a result is released, and chain-of-custody documentation is maintained on every collection. This page does not constitute medical or legal advice. **Last updated:** July 2026 You May Also Need [Nail Drug TestingNo head or body hair available? A 5-panel fingernail test covers a similar look-back window.Learn more →](https://amhnationwide.com/5-panel-fingernail-drug-test/)[ChildGuard: Environmental ExposureConcerned about a child or loved one? ChildGuard screens for exposure to drugs in their environment.Learn more →](https://amhnationwide.com/5-panel-hair-drug-test-environmental-exposure-childguard/)[Shorten the Detection WindowShortened options like 30 and 60 day hair panels are also available, useful when a urine test’s 1-3 day window is too short.Learn more →](https://amhnationwide.com/30-day-hair-drug-test/)[Hair ETG Alcohol TestAlso need alcohol testing? The hair ETG test screens for alcohol use, and can be added to the same collection.Learn more →](https://amhnationwide.com/etg-and-peth/) Frequently Asked Questions ## Common Questions No, AMH Nationwide does not offer online ordering. You must call (877) 731-6362 to arrange the lab order and be directed to a collection site. The test requires a urine sample collected under strict chain-of-custody protocols at authorized collection sites. Turnaround times vary based on the testing complexity and confirmatory steps. Contact AMH Nationwide at (877) 731-6362 for estimated timing. Yes, every non-negative screen is reviewed by a certified Medical Review Officer to ensure accurate interpretation. Testing is routed through one of five national lab networks: Quest Diagnostics, LabCorp, Omega Labs, United States Drug Testing Labs, or ExperTox. The ExperTox Unknown Drug Panel is generally used for non-DOT testing. DOT-regulated tests require federally certified urine protocols under [49 CFR Part 40](https://www.transportation.gov/odapc/part40). Sources • [SAMHSA – Mandatory Guidelines for Federal Workplace Drug Testing Programs](https://www.samhsa.gov/workplace/drug-testing) • [U.S. DOT – 49 CFR Part 40 – Procedures for Transportation Workplace Drug and Alcohol Testing Programs](https://www.transportation.gov/odapc/part40) • [CDC – National Center for Health Statistics – Drug Use FastStats](https://www.cdc.gov/nchs/fastats/drug-use.htm) • [Quest Diagnostics – Employer Solutions, Hair Testing Methodology](https://www.questdiagnostics.com/) • [LabCorp – Occupational Testing Services](https://www.labcorp.com/) ## Ready to get started? AMH Nationwide provides the lab order and arranges collection nationwide. Every non-negative result reviewed by a certified Medical Review Officer. Call (877) 731-6362 or contact us. [Call (877) 731-6362](tel:+18777316362)[Contact Us](https://amhnationwide.com/contact-us/) --- **Need a drug, alcohol, HIV or STD test?** AMH Nationwide is a national lab testing agency operating since 2004, with more than 20,000 collection sites across the United States. Hair, urine, fingernail and blood testing, panels from 5 through 19, for individuals and employers. - Call: (877) 731-6377 - Find a collection site: https://amhnationwide.com/locations/ - Full page: https://amhnationwide.com/expertox-unknown-drug-panel-how-it-works/